Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAn immunomodulatory neuropeptide

General description

An immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.

Releases ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Barmack, N.H., and Errico, P. 1993. J. Neurosci. 13, 4647.Wei, E.T., et al. 1993. Ciba Found. Symp. 172, 258.Smith, E.M., et al. 1986. Nature321, 881.Udelsman, R., et al. 1986. Nature319, 147.

Packaging

Yes

Physical form

Supplied as an acetate salt.

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH₂

Warning

Toxicity: Standard Handling (A)